Active Ingredient: Abatacept
Abatacept in combination with methotrexate is indicated for the treatment of moderate to severe active polyarticular juvenile idiopathic arthritis (JIA) in paediatric patients 6 years of age and older who have had an insufficient response to other DMARDs including at least one TNF inhibitor.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
10 mg per kg of body weight
10 mg per kg of body weight once every 14 day(s)
The recommended dose of abatacept for patients 6 to 17 years of age with juvenile idiopathic arthritis who weigh less than 75 kg is 10 mg/kg calculated based on the patient’s body weight at each administration. Paediatric patients weighing 75 kg or more should be administered abatacept following the adult dosing regimen, not to exceed a maximum dose of 1,000 mg. Abatacept should be administered as a 30-minute intravenous infusion. Following the initial administration, abatacept should be given at 2 and 4 weeks after the first infusion and every 4 weeks thereafter.
The safety and efficacy of abatacept in children below 6 years of age have not been studied and therefore, abatacept is not recommended for use in children under six years old.
30-minute intravenous infusion
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