Renal cell carcinoma

Active Ingredient: Nivolumab

Indication for Nivolumab

Population group: only adults (18 years old or older)
Therapeutic intent: Adjunct intent

Nivolumab in combination with cabozantinib is indicated for the first-line treatment of adult patients with advanced renal cell carcinoma.

For this indication, competent medicine agencies globally authorize below treatments:

240 mg every 2 weeks or 480 mg every 4 weeks

For:

Dosage regimens

Regimen A: Intravenous, 240 milligrams nivolumab, once every 2 weeks.

Regimen B: Intravenous, 480 milligrams nivolumab, once every 4 weeks.

Detailed description

The recommended dose is nivolumab administered intravenously at either 240 mg every 2 weeks or 480 mg every 4 weeks in combination with 40 mg cabozantinib administered orally every day.

Recommended doses and infusion times for intravenous administration of nivolumab in combination with oral administration of cabozantinib for RCC:

 Combination phase
Nivolumab 240 mg every 2 weeks over 30 minutes or
480 mg every 4 weeks over 60 minutes
Cabozantinib 40 mg once daily

Dosage considerations

Nivolumab must not be administered as an intravenous push or bolus injection.

Active ingredient

Nivolumab

Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody (HuMAb), which binds to the programmed death-1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2. Nivolumab potentiates T-cell responses, including anti-tumour responses, through blockade of PD-1 binding to PD-L1 and PD-L2 ligands. In syngeneic mouse models, blocking PD-1 activity resulted in decreased tumour growth.

Read more about Nivolumab

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