Portal hypertension

Active Ingredient: Propranolol

Indication for Propranolol

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

80-320 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

80 - 320 mg

Dosage regimen

From 40 To 160 mg 2 time(s) per day every day

Loading dose

80 mg

Detailed description

Dosage should be titrated to achieve approximately 25% reduction in resting heart rate. Dosing should begin with 40 mg twice daily, increasing to 80 mg twice daily depending on heart rate response. If necessary, the dose may be increased incrementally to a maximum of 160 mg twice daily.

Active ingredient

Propranolol

Propranolol is a competitive antagonist at both beta, and beta2-adrenoceptor, but has membrane stabilising activity at concentrations exceeding 1-3mg/litre, though such concentrations are rarely achieved during oral therapy. Competitive beta-blockade has been demonstrated in man by a parallel shift to the right in the dose-heart rate response curve to beta-agonists such as isoprenaline.

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