Active Ingredient: Adalimumab
Adalimumab in combination with methotrexate, is indicated for:
Adalimumab can be given as monotherapy in case of intolerance to methotrexate or when continued treatment with methotrexate is inappropriate. Adalimumab has been shown to reduce the rate of progression of joint damage as measured by X-ray and to improve physical function, when given in combination with methotrexate.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
40 - 80 mg
From 40 To 80 mg once every 14 day(s)
The recommended dose of adalimumab for adult patients with rheumatoid arthritis is 40 mg adalimumab administered every other week as a single dose via subcutaneous injection. Methotrexate should be continued during treatment with adalimumab.
Glucocorticoids, salicylates, nonsteroidal anti-inflammatory drugs, or analgesics can be continued during treatment with adalimumab.
In monotherapy, some patients who experience a decrease in their response may benefit from an increase in dose intensity to 40 mg adalimumab every week.
Available data suggest that the clinical response is usually achieved within 12 weeks of treatment.
Continued therapy should be reconsidered in a patient not responding within this time period.
Adalimumab may be available in other strengths and/or presentations depending on the individual treatment needs.
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