Dyslipidemia characterised by high TG ≥150 mg/dL

Active Ingredient: Pemafibrate

Indication for Pemafibrate

Population group: only adults (18 years old or older)
Therapeutic intent: Adjunct intent

Pemafibrate is indicated as adjunctive therapy to diet or other nonpharmacological treatment (e.g. exercise) to reduce TG and to increase HDL-C in patients with dyslipidemia characterised by high TG ≥150 mg/dL, particularly when there is evidence of associated risk such as hypertension and smoking.

For this indication, competent medicine agencies globally authorize below treatments:

0.1 mg twice daily

For:

Dosage regimens

Oral, 0.1 milligrams pemafibrate, 2 times daily. The maximum allowed total dose is 0.4 milligrams pemafibrate daily.

Detailed description

The usual adult dose is 0.1 mg twice daily. The dose may be individualized according to the patient’s age and symptoms. The maximum dose is 0.2 mg twice daily.

Elderly

No dose adjustment is necessary.

Since elderly patients often have reduced physiological function, pemafibrate should be carefully administered with close monitoring for signs of adverse reactions and clinical status of the patient.

Dosage considerations

Pemafibrate should be taken orally twice daily in the morning and evening.

Pemafibrate can be taken without regard to meals.

Active ingredient

Pemafibrate

Pemafibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist and activates PPARα by binding to this receptor and regulates the target gene expression, leading to decreased plasma triglyceride (TG) concentration, decreased triglyceride-rich lipoprotein, decreased apolipoprotein (Apo) C-3, and increased HDL-cholesterol.

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