Neutropenia due to cytotoxic chemotherapy for malignancy

Active Ingredient: Efbemalenograstim alfa

Indication for Efbemalenograstim alfa

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Efbemalenograstim alfa is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in adult patients treated with cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes).

For this indication, competent medicine agencies globally authorize below treatments:

20 mg given at least 24 h after cytotoxic chemotherapy

For:

Dosage regimens

Subcutaneous, 20 milligrams efbemalenograstim alfa, one dose.

Detailed description

One 20 mg dose of efbemalenograstim alfa is recommended for each chemotherapy cycle, given at least 24 hours after cytotoxic chemotherapy.

Efbemalenograstim alfa should be administered at least 14 days before the next dose of chemotherapy. Concomitant use with chemotherapy (i.e. administration on the same day) has been shown to potentiate myelosuppression.

Dosage considerations

The injections should be given into the thigh, abdomen, buttock or upper arm.

Active ingredient

Efbemalenograstim alfa

Human granulocyte-colony stimulating factor (G-CSF) is a glycoprotein, which regulates the production and release of neutrophils from the bone marrow. Efbemalenograstim alfa is a recombinant fusion protein containing G-CSF, a 16 amino-acid linker, and the Fc portion of human IgG2. Efbemalenograstim alfa is a sustained duration form of G-CSF due to decreased renal clearance. Efbemalenograstim alfa and other G-CSFs have identical modes of action, causing a marked increase in peripheral blood neutrophil counts within 24 hours, with minor increases in monocytes and/or lymphocytes.

Read more about Efbemalenograstim alfa

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