Efbemalenograstim alfa

Active ingredient description

Human granulocyte-colony stimulating factor (G-CSF) is a glycoprotein, which regulates the production and release of neutrophils from the bone marrow. Efbemalenograstim alfa is a recombinant fusion protein containing G-CSF, a 16 amino-acid linker, and the Fc portion of human IgG2. Efbemalenograstim alfa is a sustained duration form of G-CSF due to decreased renal clearance. Efbemalenograstim alfa and other G-CSFs have identical modes of action, causing a marked increase in peripheral blood neutrophil counts within 24 hours, with minor increases in monocytes and/or lymphocytes.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L03AA18 L Antineoplastic and immunomodulating agents → L03 Immunostimulants → L03A Immunostimulants → L03AA Colony stimulating factors
Discover more medicines within L03AA18

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
RYZNEUTA Solution for injection European Medicines Agency (EU) MPI, EU: SmPC
RYZNEUTA Solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR

External identifiers

DrugBank Drug: DB18704
KEGG Drug: D11986
RxNorm Ingredient: 2670630
UNII Identifier: 5UPW5HJW3O
EFBEMALENOGRASTIM ALFA

Medicines

Efbemalenograstim alfa is an active ingredient of these brands:

United States (US)

Lithuania (LT)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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