Chemical formula: C₂₀H₃₀O₂ Molecular mass: 302.451 g/mol PubChem compound: 446284
Icosapent ethyl is a stable ethyl ester of the omega-3 fatty acid, eicosapentaenoic acid (EPA). The mechanisms of action contributing to reduction of cardiovascular events with icosapent ethyl are not completely understood. The mechanisms are likely multi-factorial including improved lipoprotein profile with reduction of triglyceride-rich lipoproteins, anti-inflammatory, and antioxidant effects, reduction of macrophage accumulation, improved endothelial function, increased fibrous cap thickness/stability, and antiplatelet effects. Each of these mechanisms can beneficially alter the development, progression, and stabilisation of atherosclerotic plaque, as well as the implications of plaque rupture, and preclinical and clinical studies support such benefits with EPA.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C10AX06 | Omega-3-triglycerides incl. other esters and acids | C Cardiovascular system → C10 Lipid modifying agents → C10A Lipid modifying agents, plain → C10AX Other lipid modifying agents |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| VASCEPA Capsule | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| VAZKEPA Soft capsule | European Medicines Agency (EU) | MPI, EU: SmPC |
Eicosapentaenoic acid is an active ingredient of these brands:
United States (US)
Canada (CA)
Cyprus (CY)
Ecuador (EC)Hong Kong (HK)
Italy (IT)
Japan (JP)
Malta (MT)
Mexico (MX)
Netherlands (NL)
Singapore (SG)
South Africa (ZA)
Spain (ES)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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