Chemical formula: C₁₄H₁₈Cl₃N₅O₂
Ustekinumab is a fully human IgG1κ monoclonal antibody that binds with specificity to the shared p40 protein subunit of human cytokines interleukin (IL)-12 and IL-23. Ustekinumab inhibits the bioactivity of human IL-12 and IL-23 by preventing p40 from binding to the IL-12R1 receptor protein expressed on the surface of immune cells. Abnormal regulation of IL 12 and IL 23 has been associated with immune mediated diseases, such as psoriasis, psoriatic arthritis, Crohn’s disease and ulcerative colitis.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L04AC05 | Ustekinumab | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AC Interleukin inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| STELARA Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| STELARA Solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC | |
| STELARA Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Ustekinumab is an active ingredient of these brands:
Australia (AU)Brazil (BR)Canada (CA)Cyprus (CY)Ecuador (EC)Finland (FI)Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)Japan (JP)Netherlands (NL)New Zealand (NZ)Poland (PL)Singapore (SG)South Africa (ZA)Spain (ES)Tunisia (TN)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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