The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
| 1 | A | Alimentary tract and metabolism | |
| 2 | A06 | Laxatives | |
| 3 | A06A | Laxatives | |
| 4 | A06AH | Peripheral opioid receptor antagonists | |
| 5 | A06AH02 |
| Active Ingredient | Description | |
|---|---|---|
| Alvimopan |
Alvimopan is a selective antagonist of the cloned human ฮผ-opioid receptor with a Ki of 0.4 nM (0.2 ng/mL) and no measurable opioid-agonist effects in standard pharmacologic assays. The dissociation of [3H]-alvimopan from the human ฮผ-opioid receptor is slower than that of other opioid ligands, consistent with its higher affinity for the receptor. At concentrations of 1 to 10 ยตM, alvimopan demonstrated no activity at any of over 70 non-opioid receptors, enzymes, and ion channels. |
