The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
1
|
B | Blood and blood forming organs | |
2
|
B02 | Antihemorrhagics | |
3
|
B02B | Vitamin K and other hemostatics | |
4
|
B02BD | Blood coagulation factors | |
5
|
B02BD02 | Coagulation factor VIII |
| Active Ingredient |
|---|
|
Activated factor VIII acts as a cofactor for activated factor IX, accelerating the conversion of factor X to activated factor X (factor Xa). Haemophilia A is a sex-linked hereditary disorder of blood coagulation due to decreased levels of factor VIII:C. By replacement therapy the plasma levels of factor VIII are increased, thereby enabling a temporary correction of the factor deficiency and correction of the bleeding tendencies. |
|
Lonoctocog alfa is a recombinant human protein that replaces the missing coagulation factor VIII needed for effective hemostasis. Lonoctocog alfa is a single polypeptide chain with a truncated B-domain that allows for a covalent bridge to link the factor VIII heavy and light chains. Lonoctocog alfa has demonstrated a higher VWF affinity relative to full-length rFVIII. VWF stabilizes factor VIII and protects it from degradation. Activated lonoctocog alfa has an amino acid sequence identical to endogenous FVIIIa. |
|
Moroctocog alfa is a B-domain deleted recombinant coagulation factor VIII. Moroctocog alfa has functional characteristics comparable to those of endogenous factor VIII. Haemophilia A is a sex-linked hereditary disorder of blood coagulation due to decreased levels of factor VIII:C. By replacement therapy, the plasma levels of factor VIII are increased, thereby enabling a temporary correction of the factor deficiency and correction of the bleeding tendencies. |
|
Octocog alfa (Full length recombinant human coagulation factor VIII (rDNA)) is a purified protein that has 2,332 amino acids. It is produced by recombinant DNA technology in baby hamster kidney cells (BHK) into which the human factor VIII gene has been introduced. |
| Document | Type | Information Source | |
|---|---|---|---|
| ADYNOVATE Powder for injection | MPI, Generic | Health Products Regulatory Authority (ZA) | |
| ADYNOVI Powder and solvent for solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) | |
| AFSTYLA Powder and solvent for solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) | |
| BERIATE Powder and solvent for solution for injection / infusion | MPI, EU: SmPC | Medicines Authority (MT) | |
| ELOCTATE Powder for solution, lyophilized | MPI, CA: SPM | Health Products and Food Branch (CA) | |
| EMOCLOT Powder and solvent for solution for infusion | MPI, EU: SmPC | Medicines Authority (MT) | |
| HAEMOCTIN Powder and solvent for solution for injection | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| HEMOFIL M Solution for infusion | MPI, US: SPL/Old | FDA, National Drug Code (US) | |
| KOATE-DVI Powder fo solution | MPI, Generic | Health Sciences Authority (SG) | |
| KOVALTRY Powder and solvent for solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) | |
| NUWIQ Powder for solution for injection | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| OBIZUR Powder and solvent for solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) | |
| OPTIVATE Powder and solvent for solution for injection | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| REFACTO AF Powder and solvent for solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) | |
| VIHUMA Powder and solvent for solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) | |
| ZONOVATE Powder for solution, lyophilized | MPI, CA: SPM | Health Products and Food Branch (CA) |
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.