The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
1
|
L | Antineoplastic and immunomodulating agents | |
2
|
L01 | Antineoplastic agents | |
3
|
L01A | Alkylating agents | |
4
|
L01AA | Nitrogen mustard analogues | |
5
|
L01AA03 | Melphalan |
| Active Ingredient |
|---|
|
Melphalan is a bifunctional alkylating agent. Formation of carbonium intermediates from each of the two bis-2-chloroethyl groups enables alkylation through covalent binding with the 7-nitrogen of guanine on DNA, cross-linking the two DNA strands and thereby preventing cell replication. |
| Document | Type | Information Source | |
|---|---|---|---|
| ALKERAN | MPI, EU: SmPC | Health Products Regulatory Authority (IE) | |
| PHELINUN Powder and solvent for solution for infusion | MPI, EU: SmPC | European Medicines Agency (EU) |
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.