The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
| 1 | L | Antineoplastic and immunomodulating agents | |
| 2 | L01 | Antineoplastic agents | |
| 3 | L01C | Plant alkaloids and other natural products | |
| 4 | L01CX | Other plant alkaloids and natural products |
| Code | Title | |
|---|---|---|
| L01CX01 | Trabectedin |
| Active Ingredient | Description | |
|---|---|---|
| Trabectedin |
Trabectedin binds to the minor groove of deoxyribonucleic acid (DNA), bending the helix to the major groove. This binding to DNA triggers a cascade of events affecting several transcription factors, DNA binding proteins, and DNA repair pathways, resulting in perturbation of the cell cycle. Trabectedin has been shown to exert antiproliferative in vitro and in vivo activity against a range of human tumour cell lines and experimental tumours, including malignancies such as sarcoma, breast, non-small cell lung, ovarian and melanoma. |
| Title | Information Source | Document Type | |
|---|---|---|---|
| YONDELIS Powder for concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
