The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
1
|
L | Antineoplastic and immunomodulating agents | |
2
|
L03 | Immunostimulants | |
3
|
L03A | Immunostimulants | |
4
|
L03AX | Other immunostimulants | |
5
|
L03AX22 |
| Active Ingredient |
|---|
|
Leniolisib inhibits PI3K-delta by blocking the active binding site of PI3K-delta. In cell-free isolated enzyme assays, leniolisib was selective for PI3K-delta over PI3K-alpha (28-fold), PI3K-beta (43-fold), and PI3K-gamma (257-fold), as well as the broader kinome. In cell-based assays, leniolisib reduced pAkt pathway activity and inhibited proliferation and activation of B and T cell subsets. |
| Document | Type | Information Source | |
|---|---|---|---|
| JOENJA Tablet | MPI, US: SPL/PLR | FDA, National Drug Code (US) |