The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.
| Level | Code | Title | |
|---|---|---|---|
1
|
M | Musculo-skeletal system | |
2
|
M01 | Antiinflammatory and antirheumatic products | |
3
|
M01C | Specific antirheumatic agents |
| Code | Title | |
|---|---|---|
| M01CA | Quinolines | |
| M01CB | Gold preparations | |
| M01CC | Penicillamine and similar agents | |
| M01CX | Other specific antirheumatic agents |
| Active Ingredient |
|---|
|
Auranofin is an orally available compound, used to treat rheumatoid arthritis, with anti-inflammatory activities. The main mechanism of action of auranofin is through the inhibition of reduction/oxidation (redox) enzymes such as thioredoxin reductase (TrxR). The thiol ligand contained in auranofin has a high affinity for thiol and selenol groups, to which it forms stable, and irreversible, adducts. Redox enzymes such as TrxR are essential to many cellular processes, particularly in maintaining the intracellular levels of reactive oxygen species (ROS). |
|
|
|
|
|
Penicillamine is a chelating agent which aids the elimination from the body of certain heavy metal ions, including copper, lead and mercury, by forming stable soluble complexes with them that are readily excreted by the kidney. |
|
|
| Document | Type | Information Source | |
|---|---|---|---|
| CUPRIMINE Capsule | MPI, US: SPL/Old | FDA, National Drug Code (US) |