ATC Group: N05CH Melatonin receptor agonists

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of N05CH in the ATC hierarchy

Level Code Title
1 N Nervous system
2 N05 Psycholeptics
3 N05C Hypnotics and sedatives
4 N05CH Melatonin receptor agonists

Group N05CH contents

Code Title
N05CH01 Melatonin
N05CH02 Ramelteon
N05CH03

Active ingredients in N05CH

Active Ingredient

Melatonin is a naturally occurring hormone produced by the pineal gland and is structurally related to serotonin. Physiologically, melatonin secretion increases soon after the onset of darkness, peaks at 2-4 am and diminishes during the second half of the night. Melatonin is associated with the control of circadian rhythms and entrainment to the light-dark cycle. It is also associated with a hypnotic effect and increased propensity for sleep.

Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 and MT2 receptors and relative selectivity over the MT3 receptor. The activity of ramelteon at the MT1 and MT2receptors is believed to contribute to its sleep-promoting properties, as these receptors, acted upon by endogenous melatonin, are thought to be involved in the maintenance of the circadian rhythm underlying the normal sleep-wake cycle.

Tasimelteon is a circadian regulator that resets the master body clock in the suprachiasmatic nucleus (SCN). Tasimelteon acts as a Dual Melatonin Receptor Agonist (DMRA) with selective agonist activity at the MT1 and MT2 receptors. These receptors are thought to be involved in the control of circadian rhythms.

Related product monographs

Document Type Information Source  
 CIRCADIN Prolonged-release tablet MPI, EU: SmPC European Medicines Agency (EU)
 HETLIOZ Capsule MPI, US: SPL/PLR FDA, National Drug Code (US)
 HETLIOZ Hard capsule MPI, EU: SmPC European Medicines Agency (EU)
 ROZEREM Film-coated tablet MPI, US: SPL/PLR FDA, National Drug Code (US)