ATC Group: R03BB01 Ipratropium bromide

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of R03BB01 in the ATC hierarchy

Level	Code	Title
`1`	R	Respiratory system
`2`	R03	Drugs for obstructive airway diseases
`3`	R03B	Other drugs for obstructive airway diseases, inhalants
`4`	R03BB	Anticholinergics
`5`	R03BB01	Ipratropium bromide

Defined daily dose

The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. The DDD is a unit of measurement and does not necessarily reflect the recommended or Prescribed Daily Dose. Therapeutic doses for individual patients and patient groups will often differ from the DDD as they will be based on individual characteristics (such as age, weight, ethnic differences, type and severity of disease) and pharmacokinetic considerations.

Code	Route	Amount	Notes
RESPIR	Respiratory (Inhalation)	0.12 mg	(aerosol)
RESPIR	Respiratory (Inhalation)	0.12 mg	(powder)
RESPIR	Respiratory (Inhalation)	0.3 mg	(solution)

Active ingredients in R03BB01

Active Ingredient
Ipratropium
Ipratropium is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. Ipratropium appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++, which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. Ca++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol).

Related product monographs

Document	Type	Information Source
ATROVENT HFA Inhalation aerosol, metered	MPI, US: SPL/PLR	FDA, National Drug Code (US)
ATROVENT Nebuliser solution	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)