This brand name is authorized in United States
The drug ACTOPLUS MET contains a combination of these active pharmaceutical ingredients (APIs):
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1
Pioglitazone
UNII JQT35NPK6C - PIOGLITAZONE HYDROCHLORIDE
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Pioglitazone effects may be mediated by a reduction of insulin resistance. Pioglitazone appears to act via activation of specific nuclear receptors (peroxisome proliferator activated receptor gamma) leading to increased insulin sensitivity of liver, fat and skeletal muscle cells in animals. Treatment with pioglitazone has been shown to reduce hepatic glucose output and to increase peripheral glucose disposal in the case of insulin resistance. |
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2
Metformin
UNII 786Z46389E - METFORMIN HYDROCHLORIDE
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Metformin is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycaemia. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| ACTOPLUS MET XR Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: US | FDA, National Drug Code | Identifier(s): 64764-155, 64764-158, 64764-310, 64764-510 |
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