Chemical formula: C₁₉H₂₀N₂O₃S Molecular mass: 356.439 g/mol PubChem compound: 4829
Pioglitazone effects may be mediated by a reduction of insulin resistance. Pioglitazone appears to act via activation of specific nuclear receptors (peroxisome proliferator activated receptor gamma) leading to increased insulin sensitivity of liver, fat and skeletal muscle cells in animals. Treatment with pioglitazone has been shown to reduce hepatic glucose output and to increase peripheral glucose disposal in the case of insulin resistance.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A10BG03 | Pioglitazone | A Alimentary tract and metabolism → A10 Drugs used in diabetes → A10B Blood glucose lowering drugs, excl. insulins → A10BG Thiazolidinediones |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ACTOS Tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| ACTOS Tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Pioglitazone is an active ingredient of these brands:
United States (US)
Austria (AT)
Brazil (BR)
Croatia (HR)
Estonia (EE)
Finland (FI)
France (FR)
Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)Japan (JP)Lithuania (LT)
Mexico (MX)
Netherlands (NL)Poland (PL)Romania (RO)Singapore (SG)
South Africa (ZA)
Spain (ES)Turkey (TR)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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