This brand name is authorized in Austria, Estonia, Finland, Croatia, Ireland, Lithuania, Netherlands, Poland, United Kingdom, United States
The drug COMETRIQ contains one active pharmaceutical ingredient (API):
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Cabozantinib
UNII DR7ST46X58 - CABOZANTINIB S-MALATE
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Cabozantinib is a small molecule that inhibits multiple receptor tyrosine kinases (RTKs) implicated in tumour growth and angiogenesis, pathologic bone remodeling, drug resistance, and metastatic progression of cancer. Cabozantinib was evaluated for its inhibitory activity against a variety of kinases and was identified as an inhibitor of MET (hepatocyte growth factor receptor protein) and VEGF (vascular endothelial growth factor) receptors. In addition, cabozantinib inhibits other tyrosine kinases including the GAS6 receptor (AXL), RET, ROS1, TYRO3, MER, the stem cell factor receptor (KIT), TRKB, Fms-like tyrosine kinase-3 (FLT3), and TIE-2. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| COMETRIQ Capsule | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01EX07 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EX Other protein kinase inhibitors | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: EE | Ravimiamet | Identifier(s): 1643879, 1643880, 1643891, 1676190, 1687215, 1687226 |
| Country: FI | Lääkealan turvallisuus- ja kehittämiskeskus | Identifier(s): 096106, 152968, 432953 |
| Country: GB | Medicines & Healthcare Products Regulatory Agency | Identifier(s): 280100, 280105, 280108, 280109, 280110, 280112 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1073087, 1073088, 1073089, 1077694, 1077695, 1077696 |
| Country: NL | Z-Index G-Standaard, PRK | Identifier(s): 118168, 201952 |
| Country: PL | Rejestru Produktów Leczniczych | Identifier(s): 100316734, 100316740 |
| Country: US | FDA, National Drug Code | Identifier(s): 42388-013 |
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