Chemical formula: C₂₈H₂₄FN₃O₅ Molecular mass: 501.514 g/mol PubChem compound: 25102847
Cabozantinib is a small molecule that inhibits multiple receptor tyrosine kinases (RTKs) implicated in tumour growth and angiogenesis, pathologic bone remodeling, drug resistance, and metastatic progression of cancer. Cabozantinib was evaluated for its inhibitory activity against a variety of kinases and was identified as an inhibitor of MET (hepatocyte growth factor receptor protein) and VEGF (vascular endothelial growth factor) receptors. In addition, cabozantinib inhibits other tyrosine kinases including the GAS6 receptor (AXL), RET, ROS1, TYRO3, MER, the stem cell factor receptor (KIT), TRKB, Fms-like tyrosine kinase-3 (FLT3), and TIE-2.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01EX07 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EX Other protein kinase inhibitors | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| COMETRIQ Capsule | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| CABOMETYX Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Cabozantinib is an active ingredient of these brands:
Australia (AU)
Brazil (BR)
Canada (CA)
Cyprus (CY)
France (FR)
Hong Kong (HK)
Israel (IL)
Japan (JP)
New Zealand (NZ)
Romania (RO)
Singapore (SG)
Spain (ES)
Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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