DIFFERIN

This brand name is authorized in Austria, Brazil, Canada, Ecuador, Estonia, Finland, Hong Kong SAR China, Ireland, Japan, Lithuania, Netherlands, New Zealand, Poland, Singapore, South Africa, Turkey, UK, United States.

Active ingredients

The drug DIFFERIN contains one active pharmaceutical ingredient (API):

1	Adapalene UNII 1L4806J2QF - ADAPALENE
	Adapalene is a retinoid-like compound which in, in vivo and in vitro models of inflammation, has been demonstrated to possess anti-inflammatory properties. Mechanically, adapalene binds like tretinoin to specific retinoic acid nuclear receptors but, unlike tretinoin not to cytosolic receptor binding proteins. Adapalene is used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.
	Read more about Adapalene

Medication package inserts

Below package inserts are available for further reading:

Document	Type	Information Source
DIFFERIN Cream	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
D10AD03	Adapalene	D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne
Discover more medicines within D10AD03

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
BR	Câmara de Regulação do Mercado de Medicamentos	510100601161318, 510100602168316, 510100604160312, 510100605167310
CA	Health Products and Food Branch	02148749, 02231592, 02274000
EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	22.553-1-03-06, 24.737-10-02, 361770812
EE	Ravimiamet	1011429, 1011430, 1062492, 1062504, 1853108, 1865112
FI	Lääkealan turvallisuus- ja kehittämiskeskus	021053, 395715
GB	Medicines & Healthcare Products Regulatory Agency	175371, 195423, 381288, 40499, 40503
HK	Department of Health Drug Office	42052, 44125
IE	Health Products Regulatory Authority	20762, 20778, 21017, 21018
JP	医薬品医療機器総合機構	2699711Q1027
LT	Valstybinė vaistų kontrolės tarnyba	1008627, 1008628, 1066846, 1070283, 1082702, 1086734, 1086777
NL	Z-Index G-Standaard, PRK	79294
NZ	Medicines and Medical Devices Safety Authority	6825, 6826
PL	Rejestru Produktów Leczniczych	100030506, 100096617, 100098390, 100098409, 100254170, 100258623, 100260991, 100267740, 100384374, 100384397, 100419581, 100419598
SG	Health Sciences Authority	08957P, 11116P
TR	İlaç ve Tıbbi Cihaz Kurumu	8699586342608, 8699586342684
US	FDA, National Drug Code	0299-5912, 0299-5915, 0299-5918
ZA	Health Products Regulatory Authority	29/13.12/0606, 32/13.12/0476