This brand name is authorized in France, Lithuania, United States
The drug ELAHERE contains one active pharmaceutical ingredient (API):
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Mirvetuximab soravtansine
UNII 98DE7VN88D - MIRVETUXIMAB SORAVTANSINE
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Mirvetuximab soravtansine is an antibody-drug conjugate. The antibody is an engineered IgG1 directed against folate receptor alpha (FRα). The function of the antibody portion is to bind to FRα expressed on the surface of ovarian cancer cells. DM4 is a microtubule inhibitor attached to the antibody via a cleavable linker. Upon binding to FRα, mirvetuximab soravtansine is internalised followed by intracellular release of DM4 via proteolytic cleavage. DM4 disrupts the microtubule network within the cell, resulting in cell cycle arrest and apoptotic cell death. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| ELAHERE Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC | |
| ELAHERE Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01FX26 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01F Monoclonal antibodies and antibody drug conjugates → L01FX Other monoclonal antibodies | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: FR | Base de données publique des médicaments | Identifier(s): 65505616 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1101750 |
| Country: US | FDA, National Drug Code | Identifier(s): 72903-853 |
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