This brand name is authorized in Austria, Canada, Croatia, Estonia, Ireland, Italy, Lithuania, Spain.
The drug INAQOVI contains a combination of these active pharmaceutical ingredients (APIs):
1
|
UNII
776B62CQ27 - DECITABINE
|
|
Decitabine is a cytidine deoxynucleoside analogue that selectively inhibits DNA methyltransferases at low doses, resulting in gene promoter hypomethylation that can result in reactivation of tumour suppressor genes, induction of cellular differentiation or cellular senescence followed by programmed cell death. |
|
2
|
UNII
39IS23Q1EW - CEDAZURIDINE
|
|
Cedazuridine inhibits cytidine deaminase (CDA), an enzyme that is responsible for the degradation of cytidine nucleosides, including the cytidine analog decitabine. Oral administration of cedazuridine with decitabine increases the systemic exposure of decitabine via inhibition of first pass metabolism of decitabine in the gut and liver by CDA. |
|
Below package inserts are available for further reading:
| Document | Type | Information Source | |
|---|---|---|---|
| INAQOVI Film-coated tablet | MPI, EU: SmPC | European Medicines Agency (EU) |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| L01BC58 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| CA | Health Products and Food Branch | 02501600 |
| EE | Ravimiamet | 3048386 |
| ES | Centro de información online de medicamentos de la AEMPS | 1231756001 |
| IT | Agenzia del Farmaco | 050889017 |
| LT | Valstybinė vaistų kontrolės tarnyba | 1097796 |
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.