Chemical formula: C₈H₁₂N₄O₄ Molecular mass: 228.205 g/mol PubChem compound: 451668
Decitabine is a cytidine deoxynucleoside analogue that selectively inhibits DNA methyltransferases at low doses, resulting in gene promoter hypomethylation that can result in reactivation of tumour suppressor genes, induction of cellular differentiation or cellular senescence followed by programmed cell death.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BC08 | Decitabine | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| DACOGEN Powder for concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Decitabine is an active ingredient of these brands:
Cyprus (CY)Finland (FI)Hong Kong (HK)Israel (IL)Italy (IT)
Netherlands (NL)Poland (PL)Romania (RO)South Africa (ZA)Spain (ES)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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