KOMYCITAF

This brand name is authorized in South Africa

Active ingredients

The drug KOMYCITAF contains a combination of these active pharmaceutical ingredients (APIs):

1
UNII 1Q1V9V5WYQ - DOLUTEGRAVIR SODIUM
 

Dolutegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral Deoxyribonucleic acid (DNA) integration which is essential for the HIV replication cycle.

 
Read more about Dolutegravir
2
UNII G70B4ETF4S - EMTRICITABINE
 

Emtricitabine is a synthetic nucleoside analogue of cytidine with activity that is specific to HIV-1, HIV-2 and HBV. Emtricitabine is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate, which competitively inhibits HIV-1 reverse transcriptase, resulting in DNA chain termination. Emtricitabine is a weak inhibitor of mammalian DNA polymerase α, β and ε and mitochondrial DNA polymerase γ.

 
Read more about Emtricitabine
3
UNII FWF6Q91TZO - TENOFOVIR ALAFENAMIDE FUMARATE
 

Tenofovir alafenamide is a phosphonamidate prodrug of tenofovir. Tenofovir alafenamide enters primary hepatocytes by passive diffusion and by the hepatic uptake transporters OATP1B1 and OATP1B3. Tenofovir alafenamide is primarily hydrolysed to form tenofovir by carboxylesterase 1 in primary hepatocytes. Intracellular tenofovir is subsequently phosphorylated to the pharmacologically active metabolite tenofovir diphosphate. Tenofovir diphosphate inhibits HBV replication through incorporation into viral DNA by the HBV reverse transcriptase, which results in DNA chain termination. Tenofovir has activity that is specific to HBV and HIV (HIV-1 and HIV-2).

 
Read more about Tenofovir alafenamide

Medication package inserts

Below package inserts are available for further reading:

Document Type Information Source  
 KOMYCITAF Film-coated tablet MPI, EU: SmPC Health Products Regulatory Authority (ZA)

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
ZA Health Products Regulatory Authority 53/20.2.8/0468

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