Chemical formula: C₂₁H₂₉N₆O₅P Molecular mass: 476.474 g/mol PubChem compound: 9574768
Tenofovir alafenamide is a phosphonamidate prodrug of tenofovir. Tenofovir alafenamide enters primary hepatocytes by passive diffusion and by the hepatic uptake transporters OATP1B1 and OATP1B3. Tenofovir alafenamide is primarily hydrolysed to form tenofovir by carboxylesterase 1 in primary hepatocytes. Intracellular tenofovir is subsequently phosphorylated to the pharmacologically active metabolite tenofovir diphosphate. Tenofovir diphosphate inhibits HBV replication through incorporation into viral DNA by the HBV reverse transcriptase, which results in DNA chain termination. Tenofovir has activity that is specific to HBV and HIV (HIV-1 and HIV-2).
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| J05AF13 | J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| VEMLIDY Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Tenofovir alafenamide is an active ingredient of these brands:
United States (US)
Australia (AU)Austria (AT)
Brazil (BR)Canada (CA)
Croatia (HR)Cyprus (CY)Ecuador (EC)Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)Hong Kong (HK)
Ireland (IE)
Israel (IL)Italy (IT)Japan (JP)
Lithuania (LT)
Netherlands (NL)
New Zealand (NZ)Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)South Africa (ZA)
Spain (ES)
Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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