This brand name is authorized in Estonia, Lithuania
The drug LERCAPIN ACE contains a combination of these active pharmaceutical ingredients (APIs):
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1
Lercanidipine
UNII OA8TFX68PE - LERCANIDIPINE HYDROCHLORIDE
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Lercanidipine is a calcium antagonist of the dihydropyridine group and inhibits the transmembrane influx of calcium into cardiac and smooth muscle. The mechanism of its antihypertensive action is due to a direct relaxant effect on vascular smooth muscle thus lowering total peripheral resistance. |
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2
Enalapril
UNII 9O25354EPJ - ENALAPRIL MALEATE
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Enalapril is hydrolysed via hepatic CES 1 to the active metabolite enalaprilat, which acts as an ACE inhibitor. ACE is a peptidyl dipeptidase which catalyses the conversion of angiotensin I to the vasoconstrictor substance angiotensin II and hence inhibition of ACE results in decreased plasma angiotensin II. This also leads to increased plasma renin activity and decreased aldosterone secretion. The mechanism of action of enalapril is therefore primarily via the suppression of the RAAS. However, ACE is identical to kininase II, and so enalapril may also exert its effects by blocking the degradation of bradykinin, a potent vasodepressor peptide. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09BB02 | Enalapril and lercanidipine | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BB ACE inhibitors and calcium channel blockers |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: EE | Ravimiamet | Identifier(s): 1312580, 1312614, 1312625, 1312636, 1312647, 1312658, 1312669, 1312670, 1312681, 1312692, 1312704, 1312715, 1312726, 1312737, 1312748, 1312759, 1312760, 1312771, 1312782, 1312793, 1312805, 1312816, 1599329, 1599330, 1599341, 1599352, 1599363, 1599374, 1599385, 1599396, 1599408, 1599419, 1599420 |
| Country: LT | Valstybinฤ vaistลณ kontrolฤs tarnyba | Identifier(s): 1026822, 1026823, 1033867, 1033868, 1033869, 1033870, 1033871, 1033872, 1033873, 1033874, 1033875, 1033876, 1033877, 1033878, 1033879, 1033880, 1033881, 1033882, 1033883, 1033884, 1033885, 1033886, 1068427, 1073962, 1073963, 1073964, 1073965, 1073966, 1073967, 1073968, 1073969, 1073970, 1073971 |
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