Chemical formula: C₂₀H₂₈N₂O₅ Molecular mass: 376.447 g/mol PubChem compound: 5388962
Enalapril is hydrolysed via hepatic CES 1 to the active metabolite enalaprilat, which acts as an ACE inhibitor. ACE is a peptidyl dipeptidase which catalyses the conversion of angiotensin I to the vasoconstrictor substance angiotensin II and hence inhibition of ACE results in decreased plasma angiotensin II. This also leads to increased plasma renin activity and decreased aldosterone secretion. The mechanism of action of enalapril is therefore primarily via the suppression of the RAAS. However, ACE is identical to kininase II, and so enalapril may also exert its effects by blocking the degradation of bradykinin, a potent vasodepressor peptide.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09AA02 | Enalapril | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| VASOTEC Tablet | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| INNOVACE Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| AQUMELDI Orodispersible tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Enalapril is an active ingredient of these brands:
United States (US)Albania (AL)Australia (AU)
Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)Ireland (IE)Israel (IL)
Italy (IT)
Japan (JP)
Lithuania (LT)
Mexico (MX)
Poland (PL)
Romania (RO)Singapore (SG)South Africa (ZA)
Spain (ES)
Tunisia (TN)Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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