METHOFILL

This brand name is authorized in Austria, Germany, Spain, Croatia, Ireland, Poland, United Kingdom

Active ingredients

The drug METHOFILL contains one active pharmaceutical ingredient (API):

1 Methotrexate UNII YL5FZ2Y5U1 - METHOTREXATE

Methotrexate (4-amino-10-methylfolic acid) is a folic acid antagonist which inhibits the reduction of folic acid and increase of tissue cells. Methotrexate enters the cell through an active transport mechanism of reduced folates. As a result of polyglutamation of methotrexate caused by the folylpolyglutamylate enzyme, the duration of the cytotoxic effect of the drug substance in the cell increases. Read about Methotrexate

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
METHOFILL Solution for injection in pre-filled injector	Medicines & Healthcare Products Regulatory Agency (GB)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L04AX03	Methotrexate	L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AX Other immunosuppressants
Discover more medicines within L04AX03

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: DE	Bundesinstitut für Arzneimittel und Medizinprodukte	Identifier(s): 11695494, 11695502, 11695519, 11695531, 11695548, 11695560, 11695577, 11695614, 11695620, 11695637, 11695643, 11695672, 11695689, 11695695, 11695703, 11695732, 11695749, 11695755, 11695761, 11695784, 17829145, 17829174, 17829180, 17829197
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 80860, 80861, 80862, 80867, 80868, 80869, 80870, 80871, 80872, 80873
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 347765, 347770, 347772, 347774, 347777, 347779, 347781, 347783, 347785, 347787, 375712, 375714, 375716, 375718, 375720, 375724, 375726, 375728, 375730, 375732
Country: HR	Agencija za lijekove i medicinske proizvode	Identifier(s): HR-H-241871827
Country: IE	Health Products Regulatory Authority	Identifier(s): 35010, 35011, 35012, 35013, 35014, 38909, 38910, 38912, 38913, 38916
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100355869, 100369021, 100369038, 100369044, 100369050, 100369067, 100369073, 100369080, 100369096, 100369104, 100380815, 100380821, 100385244, 100421603, 100422844, 100422850, 100422867, 100422873, 100422880, 100422896