Chemical formula: C₂₀H₂₂N₈O₅ Molecular mass: 454.439 g/mol PubChem compound: 126941
Methotrexate (4-amino-10-methylfolic acid) is a folic acid antagonist which inhibits the reduction of folic acid and increase of tissue cells. Methotrexate enters the cell through an active transport mechanism of reduced folates. As a result of polyglutamation of methotrexate caused by the folylpolyglutamylate enzyme, the duration of the cytotoxic effect of the drug substance in the cell increases.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BA01 | Methotrexate | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BA Folic acid analogues |
| L04AX03 | Methotrexate | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AX Other immunosuppressants |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| JYLAMVO Oral solution | European Medicines Agency (EU) | MPI, EU: SmPC | |
| METHOTREXATE Solution for Injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| METHOTREXATE Tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| METOJECT PEN Solution for injection in pre-filled pen | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Methotrexate is an active ingredient of these brands:
United States (US)Australia (AU)Brazil (BR)Canada (CA)
Cyprus (CY)Estonia (EE)Finland (FI)Hong Kong (HK)Israel (IL)
Japan (JP)
Malta (MT)Mexico (MX)
New Zealand (NZ)Poland (PL)Romania (RO)Tunisia (TN)
Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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