This brand name is authorized in Brazil
The drug MIGRALIV contains a combination of these active pharmaceutical ingredients (APIs):
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1
Dipyrone monohydrate
UNII 6429L0L52Y - DIPYRONE
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Metamizole sodium is a pyrazolone derivative with analgesic, antipyretic and slight antiinflammatory and spasmolytic properties. It has the most potent analgesic effect of all the pyrazolone derivatives. As with other analgesics, its mechanism of action has not been elucidated in detail. It includes inhibition of prostaglandin synthesis (PGE1 and PGE2) and reversible inhibition of platelet aggregation. It inhibits cyclo-oxygenase and influences the effect of arachidonic acid. |
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2
Dihydroergotamine
UNII 81AXN7R2QT - DIHYDROERGOTAMINE MESYLATE
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Dihydroergotamine binds with high affinity to 5-HT1Dα and 5-HT1Dβ receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors. The therapeutic activity of dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors. |
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3
Caffeine
UNII 3G6A5W338E - CAFFEINE
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Caffeine is structurally related to the methylxanthines theophylline and theobromine. Caffeine’s main action is as a CNS stimulant. |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: BR | Câmara de Regulação do Mercado de Medicamentos | Identifier(s): 541820080140017, 541821020156303, 541821020156403, 541821020156503 |
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