Metamizole sodium

Chemical formula: C₁₃H₁₆N₃NaO₄S Molecular mass: 311.36 g/mol PubChem compound: 522325

Active ingredient description

Metamizole sodium is a pyrazolone derivative with analgesic, antipyretic and slight antiinflammatory and spasmolytic properties. It has the most potent analgesic effect of all the pyrazolone derivatives. As with other analgesics, its mechanism of action has not been elucidated in detail. It includes inhibition of prostaglandin synthesis (PGE1 and PGE2) and reversible inhibition of platelet aggregation. It inhibits cyclo-oxygenase and influences the effect of arachidonic acid.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code	Group title	Classification
N02BB02	Metamizole sodium	N Nervous system → N02 Analgesics → N02B Other analgesics and antipyretics → N02BB Pyrazolones
Discover more medicines within N02BB02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title	Information Source	Document Type
METAMIZOLE SODIUM Oral drops, solution	European Medicines Agency (EU)	MPI, EU: SmPC

Medicines

Metamizole sodium is an active ingredient of these brands:

Albania (AL)

ANALGIN

Austria (AT)

METAGELAN as Metamizole sodium monohydrate
NOVALGIN

Brazil (BR)

ALIVDIP as DIPYRONE
ANADOR as DIPYRONE
ATROVERAN DIP as Dipyrone monohydrate
CAFILISADOR as DIPYRONE
CONMEL as DIPYRONE
DIFEBRIL as Dipyrone
DIPIDOR as Dipyrone
DIPIFARMA as Dipyrone
DIPIGINA as Dipyrone
DIPIMED as Dipyrone
DIPIRALGIN as Dipyrone
DIPRIN as Dipyrone
DORALEX as Dipyrone monohydrate
DORFEBRIL as Dipyrone
DORFLEX UNO as Dipyrone monohydrate
HYNALGIN as Dipyrone monohydrate
LISADOR DIP as Dipyrone monohydrate
MAGNOPYROL as Dipyrone
MAXALGINA as Dipyrone
MEDALGESICO as Dipyrone monohydrate
MIRADOR as Dipyrone monohydrate
NOFEBRIN as Dipyrone monohydrate
NOVALGINA as DIPYRONE
SANTIDOR as Dipyrone
TERMOPIRONA as Dipyrone magnesium
TERMOPRIN as Dipyrone
(combination) ALGEXIN COMPOSTO as Dipyrone monohydrate
(combination) ANA-FLEX as DIPYRONE
(combination) APRACUR as DIPYRONE
(combination) APRACUR DC as DIPYRONE
(combination) APRACUR DUO as DIPYRONE
(combination) ATROVEX as Dipyrone monohydrate
(combination) BELSPAN as Dipyrone sodium monohydrate
(combination) BENEGRIP as DIPYRONE
(combination) BINOSPAN COMPOSTO as Dipyrone monohydrate
(combination) BUSCOPAN COMPOSTO as Dipyrone monohydrate
(combination) BUSCOPLEX COMPOSTO as Dipyrone monohydrate
(combination) BUSCOVERAN COMPOSTO as Dipyrone monohydrate
(combination) CEFALIV as Dipyrone
(combination) DEXALGEN as Dipyrone
(combination) DORALGINA as Dipyrone
(combination) DORALGINA DIPCAF as Dipyrone monohydrate
(combination) DORCIFLEXIN as Dipyrone monohydrate
(combination) DORFLEX as Dipyrone monohydrate
(combination) DORICIN as Dipyrone monohydrate
(combination) DORIL DC 500 as Dipyrone monohydrate
(combination) DORILEN as Dipyrone
(combination) DORILESS as Dipyrone monohydrate
(combination) DORONA CAFI as Dipyrone
(combination) DORSPAN as Dipyrone
(combination) DORTRIRELAX as Dipyrone monohydrate
(combination) DRENOGRIP as DIPYRONE
(combination) ENXAK as Dipyrone
(combination) ESCOPEN COMPOSTO as Dipyrone
(combination) FENAFLEX-ODC as Dipyrone
(combination) GRIPINEW as DIPYRONE
(combination) HIOARISTON as Dipyrone monohydrate
(combination) HIOSPAN COMPOSTO as Dipyrone
(combination) HYPOCINA COMPOSTA as Dipyrone
(combination) LISADOR as Dipyrone
(combination) MIGRALIV as Dipyrone monohydrate
(combination) MIONEVRIX as Dipyrone
(combination) MIORRELAX as Dipyrone monohydrate
(combination) NEOCOPAN COMPOSTO as Dipyrone monohydrate
(combination) NEOSALDINA as Dipyrone
(combination) NEOSALDOR as Dipyrone
(combination) NERALGYN as Dipyrone
(combination) NEVRALGEX as Dipyrone monohydrate
(combination) NOGRIPE as DIPYRONE
(combination) NOVRALFLEX as Dipyrone monohydrate
(combination) SEDALEX as Dipyrone monohydrate
(combination) SEDAMED as Dipyrone monohydrate
(combination) SEDOL as Dipyrone
(combination) SUALIV as Dipyrone monohydrate
(combination) TENSALDIN as Dipyrone
(combination) TROPINAL as Dipyrone monohydrate

Croatia (HR)

ALKAGIN as DIPYRONE
ANALGIN

Ecuador (EC)

Estonia (EE)

Finland (FI)

(combination) LITALGIN

Germany (DE)

Israel (IL)

DIPYRAZ as DIPYRONE
DULERGIN as DIPYRONE
OPTALGIN
V-DALGIN as DIPYRONE

Lithuania (LT)

Mexico (MX)

(combination) ALIVIN PLUS
(combination) BUSCAPINA COMPOSITUM
(combination) RESPICIL

Poland (PL)

Romania (RO)

South Africa (ZA)

(combination) BUSCOPAN COMPOSITUM as DIPYRONE

Spain (ES)

ALGI-MABO as METAMIZOLE MAGNESIUM
METALGIAL
NOLOTIL
(combination) BUSCAPINA COMPOSITUM

Turkey (TR)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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