This brand name is authorized in Croatia
The drug PRYLAR H contains a combination of these active pharmaceutical ingredients (APIs):
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1
Ramipril
UNII L35JN3I7SJ - RAMIPRIL
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Ramiprilat, the active metabolite of the prodrug ramipril, inhibits the enzyme dipeptidylcarboxypeptidase I (synonyms: angiotensin-converting enzyme; kininase II). In plasma and tissue this enzyme catalyses the conversion of angiotensin I to the active vasoconstrictor substance angiotensin II, as well as the breakdown of the active vasodilator bradykinin. Reduced angiotensin II formation and inhibition of bradykinin breakdown lead to vasodilatation. |
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2
Amlodipine
UNII 864V2Q084H - AMLODIPINE BESYLATE
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Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. |
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3
Hydrochlorothiazide
UNII 0J48LPH2TH - HYDROCHLOROTHIAZIDE
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Hydrochlorothiazide is a diuretic with antihypertensive properties. It acts by inhibiting the renal tubular re-absorption of sodium and chloride ions, which are excreted with an accompanying volume of water. Potassium excretion is also promoted. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09BX03 | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BX ACE inhibitors, other combinations | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: HR | Agencija za lijekove i medicinske proizvode | Identifier(s): HR-H-115715303, HR-H-378651202, HR-H-394687607, HR-H-395953294 |
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