SINEMET

This brand name is authorized in Austria, Australia, Cyprus, Germany, Ecuador, Estonia, Spain, Finland, France, Ireland, Israel, Italy, Lithuania, Malta, Mexico, Netherlands, New Zealand, Poland, Singapore, United Kingdom, United States, South Africa

Active ingredients

The drug SINEMET contains a combination of these active pharmaceutical ingredients (APIs):

1 Carbidopa UNII MNX7R8C5VO - CARBIDOPA

Carbidopa is a peripheral aromatic amino acid decarboxylase inhibitor. It prevents metabolism of levodopa to dopamine in the peripheral circulation, ensuring that a higher proportion of the dose reaches the brain, where dopamine exerts its therapeutic effects. A lower dose of levodopa can be used when it is coadministered with carbidopa, reducing the incidence and severity of peripheral side effects. Read about Carbidopa

2 Levodopa UNII 46627O600J - LEVODOPA

According to the current understanding, the symptoms of Parkinson’s disease are related to depletion of dopamine in the corpus striatum. Dopamine does not cross the blood-brain barrier. Levodopa, the precursor of dopamine, crosses the blood brain barrier and relieves the symptoms of the disease. Read about Levodopa

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
N04BA02	Levodopa and decarboxylase inhibitor	N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BA Dopa and dopa derivatives
Discover more medicines within N04BA02

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 11890T, 1242J, 1245M, 1255C
Country: DE	Bundesinstitut für Arzneimittel und Medizinprodukte	Identifier(s): 03117843, 03117978
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 25.138-05-03
Country: EE	Ravimiamet	Identifier(s): 1006861, 1006894, 1082517, 1560327, 1560338, 1560349, 1798072, 1799185
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 51794, 55866, 59334, 59872
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 158447, 406372, 513203
Country: FR	Base de données publique des médicaments	Identifier(s): 60092590, 66749235, 66818261, 69606865
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 140019, 143627, 147087, 147093, 162442, 162444, 175956, 181894, 181900, 211295, 211296, 211297, 24011, 24101, 377297, 377298
Country: IE	Health Products Regulatory Authority	Identifier(s): 13296, 13297, 13300, 46105, 46111, 46159, 61601, 61623, 61674, 66902, 66912
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 8247
Country: IT	Agenzia del Farmaco	Identifier(s): 023145030, 023145042
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1001763, 1001764, 1003483, 1003735, 1003920, 1087688, 1088351, 1090996, 1090997, 1090998, 1093502, 1093503, 1093504, 1093505
Country: MT	Medicines Authority	Identifier(s): AA565/12904
Country: MX	Comisión Federal para la Protección contra Riesgos Sanitarios	Identifier(s): 82297
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 14974, 15644, 25186, 31445, 34207
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 1819, 1820, 1821
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100061122
Country: SG	Health Sciences Authority	Identifier(s): 07202P, 14601P
Country: US	FDA, National Drug Code	Identifier(s): 0006-3915, 0006-3916, 0006-3917, 0006-3918, 0006-3919, 0006-6722, 0006-6723, 0006-6724
Country: ZA	Health Products Regulatory Authority	Identifier(s): F/5.4.1/56, P/5.4.1/141, Y/5.4.1/279