SYMKEVI

This brand name is authorized in Austria, Estonia, Spain, Finland, France, Croatia, Ireland, Italy, Lithuania, Netherlands, Poland, Romania, United Kingdom

Active ingredients

The drug SYMKEVI contains a combination of these active pharmaceutical ingredients (APIs):

1 Tezacaftor UNII 8RW88Y506K - TEZACAFTOR

2 Ivacaftor UNII 1Y740ILL1Z - IVACAFTOR

Ivacaftor is a potentiator of the CFTR protein, i.e., in vitro ivacaftor increases CFTR channel gating to enhance chloride transport in specified gating mutations with reduced channel-open probability compared to normal CFTR. Ivacaftor also potentiated the channel-open probability of R117H-CFTR, which has both low channel-open probability (gating) and reduced channel current amplitude (conductance). Read about Ivacaftor

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
R07AX31		R Respiratory system → R07 Other respiratory system products → R07A Other respiratory system products → R07AX Other respiratory system products
Discover more medicines within R07AX31

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: EE	Ravimiamet	Identifier(s): 1782390, 1834028
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 1181306001
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 396604
Country: FR	Base de données publique des médicaments	Identifier(s): 62984481, 66848831
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 367455, 391985
Country: IE	Health Products Regulatory Authority	Identifier(s): 88845, 89045
Country: IT	Agenzia del Farmaco	Identifier(s): 047307018, 047307020
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1086559, 1091497
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 197424
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100413101, 100446589
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W67229001, W67230001