Chemical formula: C₂₄H₂₈N₂O₃ Molecular mass: 392.491 g/mol PubChem compound: 16220172
Ivacaftor is a potentiator of the CFTR protein, i.e., in vitro ivacaftor increases CFTR channel gating to enhance chloride transport in specified gating mutations with reduced channel-open probability compared to normal CFTR. Ivacaftor also potentiated the channel-open probability of R117H-CFTR, which has both low channel-open probability (gating) and reduced channel current amplitude (conductance).
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R07AX02 | R Respiratory system → R07 Other respiratory system products → R07A Other respiratory system products → R07AX Other respiratory system products | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| KALYDECO Granules | European Medicines Agency (EU) | MPI, EU: SmPC | |
| KALYDECO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Ivacaftor is an active ingredient of these brands:
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Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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