TRIPLIXAM

This brand name is authorized in Brazil, Cyprus, Ecuador, Estonia, Finland, France, Hong Kong, Croatia, Lithuania, Malta, Netherlands, Poland, Romania, Singapore, Tunisia, Turkey

Active ingredients

The drug TRIPLIXAM contains a combination of these active pharmaceutical ingredients (APIs):

1 Perindopril
UNII TFT5IM1KGB - PERINDOPRIL ARGININE

Perindopril is an inhibitor of the enzyme that converts angiotensin I into angiotensin II (Angiotensin Converting Enzyme ACE). The converting enzyme, or kinase, is an exopeptidase that allows conversion of angiotensin I into the vasoconstrictor angiotensin II as well as causing the degradation of the vasodilator bradykinin into an inactive heptapeptide. Inhibition of ACE results in a reduction of angiotensin II in the plasma, which leads to increased plasma renin activity (by inhibition of the negative feedback of renin release) and reduced secretion of aldosterone. Since ACE inactivates bradykinin, inhibition of ACE also results in an increased activity of circulating and local kallikrein-kinin systems (and thus also activation of the prostaglandin system).

Read about Perindopril
2 Indapamide
UNII F089I0511L - INDAPAMIDE

Indapamide is a sulfonamide derivative with an indole ring, pharmacologically related to thiazide diuretics, which acts by inhibiting the reabsorption of sodium in the cortical dilution segment. It increases the urinary excretion of sodium and chlorides and, to a lesser extent, the excretion of potassium and magnesium, thereby increasing urine output and having an antihypertensive action.

Read about Indapamide
3 Amlodipine
UNII 1J444QC288 - AMLODIPINE

Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle.

Read about Amlodipine

Medication package inserts

Below package inserts are available for further reading:

Title Information Source Document Type  
TRIPLIXAM Film-coated tablet Health Sciences Authority (SG) MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
C09BX01 C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BX ACE inhibitors, other combinations
Discover more medicines within C09BX01

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: BR Câmara de Regulação do Mercado de Medicamentos Identifier(s): 531320100011507, 531320100011607, 531320100011707, 531320100011807
Country: EC Agencia Nacional de Regulación, Control y Vigilancia Sanitaria Identifier(s): 2490-MEE-1216, 2571-MEE-0217, 2573-MEE-0217, 2791-MEE-0617
Country: EE Ravimiamet Identifier(s): 1587876, 1587887, 1587898, 1587900, 1587911, 1587922, 1587933, 1587944, 1587955, 1587966, 1587977, 1587988, 1587999, 1588002, 1588013, 1588024, 1588035, 1588046, 1588057, 1588068, 1588079, 1588080, 1588091, 1588103, 1588114, 1650844, 1650877, 1650888, 1650901, 1650912, 1762006, 1762017, 1762028, 1762039, 1762040, 1762051, 1762062, 1762073
Country: FI Lääkealan turvallisuus- ja kehittämiskeskus Identifier(s): 042343, 449541, 460681, 479448, 494861, 502777, 562053, 590176
Country: FR Base de données publique des médicaments Identifier(s): 61442104, 62500731, 66643919, 69880873
Country: HK Department of Health Drug Office Identifier(s): 65989, 65990, 65991, 65992
Country: HR Agencija za lijekove i medicinske proizvode Identifier(s): HR-H-175417914, HR-H-385858036, HR-H-826085198, HR-H-919762076
Country: LT Valstybinė vaistų kontrolės tarnyba Identifier(s): 1066867, 1066868, 1066869, 1066870, 1072878, 1072879, 1072880, 1072881, 1072882, 1072883, 1072884, 1072885, 1072886, 1072887, 1072888, 1072889, 1072890, 1072891, 1072892, 1072893, 1072894, 1072895, 1072896, 1072897, 1072898, 1073715, 1073716, 1073717, 1073718, 1073719, 1084848, 1084849, 1084850, 1084851, 1084852, 1084853, 1084854, 1084855
Country: MT Medicines Authority Identifier(s): MA066/02002, MA066/02003, MA066/02004, MA066/02005
Country: NL Z-Index G-Standaard, PRK Identifier(s): 116173, 116181, 116203, 116211
Country: PL Rejestru Produktów Leczniczych Identifier(s): 100314971, 100314994, 100315019, 100315048
Country: RO Agenția Națională a Medicamentului și a Dispozitivelor Medicale Identifier(s): W61001001, W61001002, W61001003, W61001004, W61001005, W61001006, W61001007, W61001008, W61002001, W61002002, W61002003, W61002004, W61002005, W61002006, W61002007, W61002008, W61003001, W61003002, W61003003, W61003004, W61003005, W61003006, W61003007, W61003008, W61004001, W61004002, W61004003, W61004004, W61004005, W61004006, W61004007, W61004008
Country: SG Health Sciences Authority Identifier(s): 15010P, 15011P, 15012P, 15013P, 15014P
Country: TN Direction de la Pharmacie et du Médicament Identifier(s): 9254201, 9254202, 9254203, 9254204
Country: TR İlaç ve Tıbbi Cihaz Kurumu Identifier(s): 8699552090823, 8699552090830, 8699552090847, 8699552090854

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