This brand name is authorized in Canada, Cyprus, Spain, France, Ireland, Italy, Malta, Mexico, United Kingdom, United States, South Africa
The drug ZESTORETIC contains a combination of these active pharmaceutical ingredients (APIs):
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1
Lisinopril dihydrate
UNII 7Q3P4BS2FD - LISINOPRIL ANHYDROUS
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Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin-converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of angiotensin II which results in decreased vasopressor activity and reduced aldosterone secretion. |
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2
Hydrochlorothiazide
UNII 0J48LPH2TH - HYDROCHLOROTHIAZIDE
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Hydrochlorothiazide is a diuretic with antihypertensive properties. It acts by inhibiting the renal tubular re-absorption of sodium and chloride ions, which are excreted with an accompanying volume of water. Potassium excretion is also promoted. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| ZESTORETIC Tablet | FDA, National Drug Code (US) | MPI, US: SPL/Old |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09BA03 | Lisinopril and diuretics | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BA ACE inhibitors and diuretics |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: CA | Health Products and Food Branch | Identifier(s): 02045729, 02045737, 02103729 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 59582 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 66434780 |
| Country: GB | Medicines & Healthcare Products Regulatory Agency | Identifier(s): 147675, 179007, 31432, 31444, 374211, 378899 |
| Country: IE | Health Products Regulatory Authority | Identifier(s): 52270, 52299 |
| Country: IT | Agenzia del Farmaco | Identifier(s): 027482013 |
| Country: MT | Medicines Authority | Identifier(s): MA1310/00301 |
| Country: MX | Comisión Federal para la Protección contra Riesgos Sanitarios | Identifier(s): 159M90 |
| Country: US | FDA, National Drug Code | Identifier(s): 52427-435, 52427-436, 52427-437 |
| Country: ZA | Health Products Regulatory Authority | Identifier(s): 27/7.1.3/0366, 29/7.1.3/0652 |
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