Chemical formula: C₂₁H₃₁N₃O₅ Molecular mass: 405.488 g/mol PubChem compound: 5362119
Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin-converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of angiotensin II which results in decreased vasopressor activity and reduced aldosterone secretion.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09AA03 | Lisinopril | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ZESTRIL Tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| ZESTRIL Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| PRINIVIL Tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Lisinopril is an active ingredient of these brands:
United States (US)
Austria (AT)
Brazil (BR)Canada (CA)
Croatia (HR)
Cyprus (CY)
Estonia (EE)
Finland (FI)France (FR)
Germany (DE)
Hong Kong (HK)Ireland (IE)
Italy (IT)
Malta (MT)
Mexico (MX)
Netherlands (NL)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)South Africa (ZA)
Spain (ES)
Turkey (TR)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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