ICD-10 Specific code E84: Cystic fibrosis

Specific codes in ICD-10 are unique alphanumeric designations used to identify and categorize diseases, disorders, and conditions. They consist of 3-5 characters, including both letters and numbers, that provide a high level of detail and specificity.

Translations

Language Translation
Flag for English language  English Cystic fibrosis
Flag for French language  French Fibrose kystique

Hierarchical position

Level Code Title
1 IV Endocrine, nutritional and metabolic diseases
2 E70-E90 Metabolic disorders
3 E84 Cystic fibrosis

Contents

Code Title
E84.0 Cystic fibrosis with pulmonary manifestations
E84.1 Cystic fibrosis with intestinal manifestations
E84.8 Cystic fibrosis with other manifestations
E84.9 Cystic fibrosis, unspecified

Indicated medicines

Active Ingredient Description
Dornase alfa

Recombinant human DNase is a genetically engineered version of a naturally occurring human enzyme which cleaves extracellular DNA. In vitro, dornase alfa hydrolyses DNA in sputum and greatly reduces the viscoelasticity of cystic fibrosis sputum.

Ivacaftor

Ivacaftor is a potentiator of the CFTR protein, i.e., in vitro ivacaftor increases CFTR channel gating to enhance chloride transport in specified gating mutations with reduced channel-open probability compared to normal CFTR. Ivacaftor also potentiated the channel-open probability of R117H-CFTR, which has both low channel-open probability (gating) and reduced channel current amplitude (conductance).

Mannitol

Mannitol is a naturally occurring sugar alcohol used clinically primarily for its osmotic diuretic properties.