Active Ingredient: Tocilizumab
Tocilizumab is indicated for the treatment of chimeric antigen receptor (CAR) T cell-induced severe or life-threatening cytokine release syndrome (CRS) in adults and paediatric patients 2 years of age and older.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
8 - 12 mg per kg of body weight
From 8 To 12 mg per kg of body weight once every day
The recommended posology for treatment of CRS given as a 60-minute intravenous infusion is 8 mg/kg in patients weighing greer than or equal to 30 kg or 12 mg/kg in patients weighing less than 30 kg. Tocilizumab can be given alone or in combination with corticosteroids.
If no clinical improvement in the signs and symptoms of CRS occurs after the first dose, up to 3 additional doses of tocilizumab may be administered. The interval between consecutive doses should be at least 8 hours. Doses exceeding 800 mg per infusion are not recommended in CRS patients.
Patients with severe or life-threatening CRS frequently have cytopenias or elevated ALT or AST due to the underlying malignancy, preceding lymphodepleting chemotherapy or the CRS.
It should be administered as an intravenous infusion over 1 hour.
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