Tocilizumab binds specifically to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R). IL-6 is involved in diverse physiological processes such as T-cell activation, induction of immunoglobulin secretion, induction of hepatic acute phase protein synthesis and stimulation of haemopoiesis. IL-6 has been implicated in the pathogenesis of diseases including inflammatory diseases, osteoporosis and neoplasia.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L04AC07 | Tocilizumab | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AC Interleukin inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| RoACTEMRA Solution for injection in pre-filled syringe | European Medicines Agency (EU) | MPI, EU: SmPC | |
| ACTEMRA Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| RoACTEMRA Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Tocilizumab is an active ingredient of these brands:
Australia (AU)Brazil (BR)Canada (CA)Cyprus (CY)Ecuador (EC)Finland (FI)Hong Kong (HK)Israel (IL)Japan (JP)Netherlands (NL)New Zealand (NZ)Poland (PL)Romania (RO)Singapore (SG)South Africa (ZA)Tunisia (TN)Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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