Active Ingredient: Alitretinoin
Alitretinoin is indicated for the topical treatment of cutaneous lesions in patients with AIDS related Kaposi’s sarcoma (KS) when:
For this indication, competent medicine agencies globally authorize below treatments:
Cutaneous
2 - 4 {spreads}
From 1 To 2 {spreads} 2 time(s) per day every day for 84 day(s)
Alitretinoin therapy should only be initiated and maintained by specialist physicians experienced in the treatment of patients with KS.
Patients should apply alitretinoin to cutaneous KS lesions using sufficient gel so as to cover each lesion with a generous coating.
Frequency of application Patients should initially apply alitretinoin twice a day to cutaneous KS lesions. The application frequency can be increased stepwise to three or four times a day according to individual lesion tolerance, allowing no less than two weeks between dose increases. The frequency of application should be adjusted for each lesion independently. If application site toxicity occurs, the application frequency can be reduced as described below. There are no data on the efficacy of alitretinoin applied less frequently than twice daily.
Patients should wash their hands before and after applications; it is not necessary to wear gloves. The gel must be allowed to dry for three to five minutes before covering with clothing. Occlusive dressings should be avoided.
Care must be taken to avoid application of the gel to normal skin surrounding the lesions.
Gel should not be applied on or near eyes or mucosal surfaces of the body. Showering, bathing, or swimming for at least three hours after any application should be avoided.
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