Chemical formula: C₂₀H₂₈O₂ Molecular mass: 300.435 g/mol PubChem compound: 449171
Alitretinoin is a naturally-occurring endogenous hormone related to vitamin A, binds to and activates all known intracellular retinoid receptor subtypes (RAR, RAR, RAR, RXR, RXR, RXR). The efficacy of alitretinoin in treating KS lesions may be related to the demonstrated ability of alitretinoin to inhibit the in vitro growth of KS cells.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D11AH04 | Alitretinoin | D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AH Agents for dermatitis, excluding corticosteroids |
| L01XF02 | Alitretinoin | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XF Retinoids for cancer treatment |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| PANRETIN Gel | European Medicines Agency (EU) | MPI, EU: SmPC | |
| TOCTINO Capsule, soft | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Alitretinoin is an active ingredient of these brands:
United States (US)Canada (CA)Finland (FI)Israel (IL)Lithuania (LT)New Zealand (NZ)Spain (ES)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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