Chronic obstructive pulmonary disease

Active Ingredient: Ensifentrine

Indication for Ensifentrine

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Ensifentrine is indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adult patients.

For this indication, competent medicine agencies globally authorize below treatments:

3 mg twice daily

For:

Dosage regimens

Respiratory (Inhalation), 3 milligrams ensifentrine, 2 times daily.

Detailed description

The recommended dosage of ensifentrine is 3 mg twice daily, once in the morning and once in the evening, administered by oral inhalation using a standard jet nebulizer with a mouthpiece.

Drug compatibility:

Compatibility of ensifentrine mixed with other drugs has not been established. Ensifentrine should not be physically mixed with other drugs or added to solutions containing other drugs.

Active ingredient

Ensifentrine

Ensifentrine is a small molecule that is an inhibitor of the PDE3 and PDE4 enzymes. PDE3 primarily hydrolyzes the second-messenger molecule cyclic adenosine monophosphate (cAMP) but is also capable of hydrolyzing cyclic guanosine monophosphate (cGMP). PDE4 hydrolyzes cAMP only. Inhibition of PDE3 and PDE4 results in accumulation of intracellular levels of cAMP and/or cGMP, resulting in various downstream signalling effects.

Read more about Ensifentrine

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