Active Ingredient: Mometasone
For this indication, competent medicine agencies globally authorize below treatments:
Respiratory (Inhalation)
400 - 800 ug
From 400 To 800 ug once every day
The recommended starting dose is 400 micrograms twice daily, which is the maximum recommended dose. When symptoms are controlled, titrate mometasone to the lowest effective dose.
In patients with severe asthma and previously receiving oral corticosteroids, mometasone will be initiated concurrently with the patient’s usual maintenance dose of systemic corticosteroid. After approximately one week, gradual withdrawal of the systemic corticosteroid can be initiated by reducing the daily or alternate daily dose. The next reduction is made after an interval of one to two weeks, depending on the response of the patient. Generally, these decrements are not to exceed 2.5 mg of prednisone daily, or its equivalent.
A slow rate of withdrawal is strongly recommended. During withdrawal of oral corticosteroids, patients must be carefully monitored for signs of unstable asthma, including objective measures of airway function, and for adrenal insufficiency.
The patient should be instructed that mometasone 200 micrograms is not intended to be used “on demand” as a reliever medication to treat acute symptoms and that this product must be taken regularly to maintain therapeutic benefit even when he or she is asymptomatic.
Severe asthma: continuous symptoms; frequent exacerbations; frequent night-time asthma symptoms; physical activities limited by asthma symptoms; PEF or FEV1 ≤60% predicted, variability >30%.
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