Active Ingredient: Rifampicin
In combination with other active anti-tuberculosis drugs in the treatment of all forms of tuberculosis, including fresh, advanced, chronic and drug-resistant cases. Rifampicin is also effective against most atypical strains of Mycobacteria.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
8 - 12 mg per kg of body weight
From 8 To 12 mg per kg of body weight once every day
Rifampicin should be given with other effective anti-tuberculosis drugs to prevent the possible emergence of rifampicin-resistant strains of Mycobacteria.
The recommended single daily dose in tuberculosis is 8-12 mg/kg.
Usual Daily dose:
Patients weighing less than 50 kg – 450 mg.
Patients weighing 50 kg or more – 600 mg.
In elderly patients, the renal excretion of rifampicin is decreased proportionally with physiological decrease of renal function; due to compensatory increase of liver excretion, the terminal half-life in serum is similar to that of younger patients. However, as increased blood levels have been noted in one study of rifampicin in elderly patients, caution should be exercised in using rifampicin in such patients, especially if there is evidence of impaired liver function.
The daily dose of rifampicin, calculated from the patient’s body weight, should preferably be taken at least 30 minutes before a meal or 2 hours after a meal to ensure rapid and complete absorption.
Intravenous
600 - 600 mg
From 600 To 600 mg once every day
A single daily administration of 600mg given by intravenous infusion over 2 to 3 hours has been found to be effective and well tolerated for adult patients. Serum concentrations following this dosage regimen are similar to those obtained after 600mg by mouth.
In elderly patients, the renal excretion of rifampicin is decreased proportionally with physiological decrease of renal function; due to compensatory increase of liver excretion, the terminal half-life in serum is similar to that of younger patients. However, as increased blood levels have been noted in one study of rifampicin in elderly patients, caution should be exercised in using rifampicin in such patients, especially if there is evidence of impaired liver function.
Intravenous infusion over 2 to 3 hours.
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