Rifampicin

Chemical formula: C₄₃H₅₈N₄O₁₂  Molecular mass: 822.94 g/mol  PubChem compound: 5381226

Active ingredient description

Rifampicin is an active bactericidial antituberculosis drug which is particularly active against the rapidly growing extracellular organisms and also has bactericidial activity intracellularly. Rifampicin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
J04AB02 Rifampicin J Antiinfectives for systemic use → J04 Antimycobacterials → J04A Drugs for treatment of tuberculosis → J04AB Antibiotics
Discover more medicines within J04AB02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 RIFADIN Solvent MPI, EU: SmPC Medicines & Healthcare Products Regulatory Agency (GB)
 RIFADIN Capsule MPI, EU: SmPC Medicines & Healthcare Products Regulatory Agency (GB)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 13292-46-1
DrugBank Drug: DB01045
KEGG Drug: D00211
PubChem Compound: 5381226
RxNorm Ingredient: 9384
SNOMED-CT Concept: 387159009
Rifampicin (substance)
UNII Identifier: VJT6J7R4TR
RIFAMPIN

Medicines

Rifampicin is an active ingredient of these brands:

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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