Active Ingredient: Flumazenil
For the reversal of conscious sedation induced with benzodiazepines in children above 1 year of age.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
10 - 50 ug per kg of body weight
From 2 To 10 ug per kg of body weight 5 time(s) per day every day
For the reversal of conscious sedation induced with benzodiazepines in children above 1 year of age, the recommended initial dose is 10 micrograms/kg (up to 200 micrograms) administered intravenously over 15 seconds. If the desired level of consciousness is not obtained after waiting an additional 45 seconds, further injection of 10 micrograms/kg may be administered (up to 200 micrograms) and repeated at 60 second intervals where necessary (a maximum of 4 times) to a maximum total dose of 50 micrograms/kg or 1000 micrograms, whichever is lower. The dose should be individualised based on the patient’s response. No data are available on the safety and efficacy of repeated administration of flumazenil to children for re-sedation.
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